ABSTRACT
<p><b>OBJECTIVE</b>To detect aquaporin-1 mRNA (AQP1) expression in human oligohydramnios placenta and fetal membranes.</p><p><b>METHODS</b>Placenta and fetal membranes samples were obtained from 5 women with oligohydramnios and 5 with normal amniotic fluid volume. AQP-1 mRNA expression in the tissue samples was detected by semi-quantitative RT-PCR.</p><p><b>RESULTS</b>The expression of AQP1 mRNA was significantly lower in oligohydramnios placenta than in normal pregnancy placenta at term (P<0.05), and also significantly lower in oligohydramnios fetal membranes than in normal fetal membranes at term (P<0.05).</p><p><b>CONCLUSION</b>Alterations in AQP1 mRNA expressions in human placenta and fetal membranes may play an important role in the disorder of maternal-fetal fluid exchange and amniotic fluid volume.</p>